Pengaruh Variasi Kadar Pengisi Laktosa dan Manitol terhadap Sifat Fisik Granul sebagai Produk Antara Tablet Effervescent Ekstrak Daun Senna (Cassia acutifolia)

Senna leaf (Cassia acutifolia) is a plant that widely known by the public to treat constipation. products have weaknesses in form of an unpleasant aroma and taste use inappropriate doses. This study aims determine effect variations levels lactose mannitol as filler on physical properties effervescent granules senna extract. Effervescent were made using melting method with ratio 25% : 75%, 50% 50%, 75% 25%, while extraction for leaves used infundation distilled water solvent. The obtained tested flow time, angle repose, setting moisture content. data analyzed theoretical approach statistical test analysis variance (ANOVA) 95% confidence level. results showed groups could affect content repose but had no compressibility time granules. Keywords Cassia acutifolia, sennoside, laxative, granules, mannitol,